New Methodology for the Synthesis of 3-Substituted Coumarins via Pd-Catalyzed Site-Selective Cross-Coupling Reactions

Abstract

A particularly useful, easy and concise synthesis of diversified 3-aryl coumarin was achieved using Heck coupling reactions between coumarin and aryliodides. The introduction of the aryl moiety occurred regioselective at the 3-position of the heteroaromatic ring.