COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity

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dc.contributor.authorDavid, Suzana
dc.contributor.authorDorado, Guillermo
dc.contributor.authorDuarte, Elsa Leclerc
dc.contributor.authorDavid-Bosne, Stephanie
dc.contributor.authorTrigueiro-Louro, João
dc.contributor.authorRebelo de Andrade, Helena
dc.date.accessioned2022-07-15T15:23:56Z
dc.date.available2022-07-15T15:23:56Z
dc.date.issued2022-03-29
dc.description.abstractCOVID-19 is a new complex multisystem disease caused by the novel coronavirus SARS-CoV-2. In slightly over 2 years, it infected nearly 500 million and killed 6 million human beings worldwide, causing an unprecedented coronavirus pandemic. Currently, the international scientific community is engaged in elucidating the molecular mechanisms of the pathophysiology of SARS-CoV-2 infection as a basis of scientific developments for the future control of COVID-19. Global exome and genome analysis efforts work to define the human genetics of protective immunity to SARS-CoV-2 infection. Here, we review the current knowledge regarding the SARS-CoV-2 infection, the implications of COVID-19 to Public Health and discuss genotype to phenotype association approaches that could be exploited through the selection of candidate genes to identify the genetic determinants of severe COVID-19.por
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dc.identifier.citationDavid, S., Dorado, G., Duarte, E.L. et al. COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity. Immunogenetics (2022). https://doi.org/10.1007/s00251-022-01261-wpor
dc.identifier.doihttps://doi.org/10.1007/s00251-022-01261-wpor
dc.identifier.scientificarea241por
dc.identifier.sharewithDVM Publicações em Revistas Internacionais com arbitragem científicapor
dc.identifier.urihttp://hdl.handle.net/10174/32321
dc.language.isoporpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.rightsembargoedAccesspor
dc.subjectCandidate gene association studies (CGAS)por
dc.subjectCOVID19por
dc.subjectPublic Healthpor
dc.subjectsusceptibility to infectionpor
dc.subjectGenome-wide association studies (GWAS)por
dc.subjectGenetic determinants of severe diseasepor
dc.titleCOVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severitypor
dc.typearticlepor

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