Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives
| dc.contributor.author | Burke, Anthony | |
| dc.contributor.author | Marques, Carolina | |
| dc.contributor.author | Peixoto, Daniela | |
| dc.contributor.editor | Ward, MD | |
| dc.date.accessioned | 2016-01-13T17:31:41Z | |
| dc.date.available | 2016-01-13T17:31:41Z | |
| dc.date.issued | 2015-02-09 | |
| dc.description.abstract | We report an innovative and simple three step high yielding synthesis of a library of 14 chiral isoquinolinone and azepinone derivatives with benzyl, pyridyl and thiophene cores starting from amidoarylboronic acid aldehydes. These products have potential for treating neuro-degenerative diseases. The key reaction in this synthetic pathway was an efficient metal-catalyzed (with Rh, Cu and Pd catalysts) intramolecular cyclization. A maximum yield of 87% was obtained using a Rh(I) catalyst. | por |
| dc.identifier.authoremail | ajb@uevora.pt | |
| dc.identifier.authoremail | carolsmarq@gmail.com | |
| dc.identifier.authoremail | danielaaspeixoto@gmail.com | |
| dc.identifier.doi | 10.1039/c5ra00404g | por |
| dc.identifier.ismn | WOS:000350220400038 | |
| dc.identifier.issn | 2046-2069 | |
| dc.identifier.pagina | 20108-20114 | |
| dc.identifier.revista | RSC Advances | |
| dc.identifier.scientificarea | 310 | por |
| dc.identifier.uri | http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA00404G#!divAbstract | |
| dc.identifier.uri | http://hdl.handle.net/10174/16611 | |
| dc.identifier.volume | 5 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | RSC | por |
| dc.rights | openAccess | por |
| dc.subject | Catálise | por |
| dc.subject | Alzheimer | por |
| dc.title | Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives | por |
| dc.type | article | por |