Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization

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dc.contributor.authorTeixeira, Fátima C.
dc.contributor.authorAntunes, Inês F.
dc.contributor.authorCurto, M. João M.
dc.contributor.authorNeves, M.
dc.contributor.authorTeixeira, António P. S.
dc.date.accessioned2012-01-23T15:01:38Z
dc.date.available2012-01-23T15:01:38Z
dc.date.issued2009
dc.description.abstractBisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain with different lengths ((CH2)n, n = 0-5) between the indazole ring and the bisphosphonate group.por
dc.identifier.authoremailfatima.teixeira@ineti.pt
dc.identifier.authoremailnd
dc.identifier.authoremailnd
dc.identifier.authoremailnd
dc.identifier.authoremailapsteix@uevora.pt
dc.identifier.issn1551-7012
dc.identifier.scientificarea307por
dc.identifier.sharewithQUI -Artigo em Revista Internacional com Arbitragem Científicapor
dc.identifier.urihttp://hdl.handle.net/10174/4027
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherArkat USA, Incpor
dc.rightsopenAccesspor
dc.subjectBisphosphonatespor
dc.subjectIndazolespor
dc.subjectN-1 and N-2 isomers,por
dc.subjectspectroscopic characterizationpor
dc.titleNovel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterizationpor
dc.typearticlepor
degois.publication.firstPage69por
degois.publication.issue2009por
degois.publication.lastPage84por
degois.publication.locationUSApor
degois.publication.titleArkivocpor
degois.publication.volumexipor

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