Endocrine Disrupting Chemicals in Patients with Chronic Obstructive Pulmonary Diseases

Abstract

The study of indoor environmental quality as well as the development and progression of chronic respiratory diseases have received a great deal of attention in the past few years. However, most of those surveys focus on the effects of particulate matter (PM) and biological contaminants (fungi and bacteria) and evidences on the effects of endocrine disrupting chemicals (EDCs) in these pathologies are limited. Hence, RESPIRA project aims to contribute towards a better understanding of the role of multiple stressors in respiratory diseases by providing data on the levels and effects of EDCs in patients with Chronic Obstructive Pulmonary Disease (COPD) and control individuals from Estarreja region (NW Portugal). Here we will summarize the results obtained for phenolic compounds (parabens, triclosan and triclocarban) in matched human and indoor environmental samples (house dust) from COPD patients. Overall, the concentrations in dust samples are one to two orders of magnitude higher that the concentrations in human urine. Triclosan was detected in all the dust samples, triclocarban was detected in 82% of the dust samples and parabens in 90% to 100% of the samples. In urine samples, triclosan was detected in 56% of the samples, triclocarban was always bellow detection limit (0.25 ng/mL) and parabens detection frequency varied widely (23-84%). Interestingly, the highest level reported in dust for triclosan (1200 ng/g) corresponded to the house of the patient with the highest triclosan concentration in urine (140 ng/mL). Acknowledgements: This work was financed by Labex DRIIHM (PIA), via OHMI Estarreja – International Observatory Hommes-Millieux, tool of CNRS/INEE - National Center for Scientific Research/Institute of Ecology and Environment and Labex DRIIHM, French programme "Investissements d'Avenir" (ANR-11-LABX-0010) which is managed by the ANR. Further financial support was provided by the Ministry of Education, Culture, Sports, Science, and Technology, Japan (MEXT) to the LaMer project. Further funding was provided by Universidade de Aveiro, in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19 (A.C.A. Sousa). Endocrine Disrupting Chemicals in Patients with Chronic Obstructive Pulmonary Diseases BOOK OF